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Anti-Epileptic Drugs
Anti-Epileptic Drugs Na+ channel antagonists These agents block sodium channels in the CNS by binding and prolonging the inactivated state of channel. Their action is use-dependent, so they are more active during seizures characterised by excessive neural activity....Anaesthetics
Anaesthetics Anaesthesia is a controlled temporary loss of awareness, with varying degrees of pain relief (analgesia), loss of memory (amnesia) and muscle paralysis. General anaesthesia: this is believed to potentiate GABAA receptors and K+ channels and inhibit...GABA-ergic drugs
GABA Drugs GABA is made from glutamate using an enzyme that is only found in GABA neurones. It binds GABA(A) receptors which are ionotropic and permeable to Cl- ions which hyperpolarizes neurones It also binds to GABA(B) receptors, which are metabotropic and Gi...Autonomic System Drugs
Autonomic System Drugs Nicotinic Agents Nicotinic receptors are present both at the autonomic ganglia and at the neuromuscular junction (NMJ). NMJ blockers (muscle relaxants) are either non-depolarising, which work by directly blocking the receptor or depolarising,...
