Fall in a Paediatric Patient

Try out this paediatric case and test your clinical knowledge. The answers are at the bottom.

Questions

A 16yearoldboy presents to A&E having fallen over at home. On questioning his mother reports that he has become more confused these past few months and often lashes out inappropriately.

Observations:

SpO2: 97%
Temperature: 37.2
BP: 108/69
HR: 92
RR: 30

Examination:

A: Patent. Maintaining own airway

B: NC 2L/min FiO2 21%.Chest clear, trachea central. pCXR: NAD

C: CRT 2s, HS 1+2. Bedside echo: Good LV+RV function

D: GCS 12 (E4V4M4). PEARL. BM 5.3. Rigidity bilaterally in legs. Fine tremor bilaterally.

E: Abdomen: Liver edge palpable, abdomen SNT

Q1: What are the features of the Glasgow Coma Scale (GCS) and what is its significance clinically?

Some initial bloods are taken:

Q2: Comment on the blood results

An initial CT head is reported as inconclusive and thus an urgent MRI brain is performed.

Image 1: Case courtesy of Dr Ian Bickle, Radiopaedia.org. From the case rID: 50303

 

Q3: Comment on the MRI results. What is the diagnosis?

Q4: What other investigations would confirm the diagnosis?

 

Answers

Reveal the Answers

Answer to Question 1

The GCS is a helpful tool to assess a patient’s level of consciousness. A GCS score of 8 orless is concerning clinically as at this level of consciousness there is a risk of a patient being unable to maintain their own airway. As such, most patients with a GCS score of < 8 who are at real risk of aspirating will require definitive airway management (ETT or SGAdoesn’t protect against aspiration).

Eyes (E) Verbal (V) Motor (M)
6- Obeys commands
5- Orientated 5- Localises to pain
4- Spontaneous 4- Confused 4- Withdraws from pain
3- To speech 3-Inappropriate words 3- Abnormal flexion
2- To pain 2-Inappropriate sounds 2- Abnormal extension
1- No response 1- No response 1- No response

Answer to Question 2

The main finding on the bloods is a metabolic (lactic) acidosis, indicating tissue or organhypoxia and/ordysfunction. In this case, the organ is likely the liver, as the AST and ALT aregrossly elevated. The AST and ALT are also elevated significantly in comparison to the ALPand GGT, which suggests the pathology is within the liver itself andnot due any biliarypathology. The high respiratory rate and low pCO2 indicates a degree of respiratory compensation, but this is not enough to offset the significant metabolic acidosis

Answer to Question 3

 This is a FLAIR MRI (T2 weighted with CSF signal subtracted). There is hyperattenuationin both basal ganglia, which would explain his parkinsonian signs (rigidity, tremor).Combined with the liver dysfunction, the most likely diagnosis in this case is Wilson’sDisease.

Answer to Question 4

 Serum copper, urinarycopper,and serum ceruloplasmin can bemeasured. Kaiserflescher rings and blue nails may also be present. The diagnosis is often confirmed withgenetic testing ofATP7B, a gene that encodes a copper transport protein.

Serum Copper Low
Urinary Copper High
Serum Ceruloplasmin Low

Sources

Image 1: Case courtesy of Dr Paresh K Desai, <a

href=”https://radiopaedia.org/”>Radiopaedia.org</a>.From the case <a

href=”https://radiopaedia.org/cases/12107″>rID:12107</a>

Dr Amol Joshi
University of Cambridge

About The Author

This case is written by Dr Amol Joshi who has an interest in writing medical puzzles.